5-Bromo-1,2,3-trimethoxybenzene → HCID 66987404, compound

Participants

Reaction Steps

First, magnesium was added to 1-bromo-3,4,5-trimethoxybenzene as a starting material, as shown in Reaction 6, and then 3-bromobenzaldehyde was added thereto to obtain a compound. Thus obtained compound was oxidized using PDC to obtain a Compound 21 derivative [(3-bromophenyl)(3,4,5-trimethoxyphenyl)methanone]. Thus obtained compound and thiophen-3-boronic acid were subjected to the Suzuki reaction, in the same manner as in the synthesis of Compound 457, to obtain Compound 568.

Provenance & Evidence