HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 3-Hydroxypyrrolidine-1-carbonyl Chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Triphosgene | HCID 94429 | — |
| Reactant | 4-Hydroxypyrrolidine | HCID 98210 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-Hydroxypyrrolidine-1-carbonyl Chloride | HCID 86630060 | — |
Reaction Conditions
| Temperature | 0 °C |
|---|
Reaction Steps
To a solution of pyrrolidin-3-ol (0.083 g, 0.955 mmol) in dry THF (5 mL) was added DIPEA (0.3 mL, 1.91 mmol) and cooled 0° C. To the resulting mixture was added triphosgene (0.127 g, 0.429 mmol) and the mixture was stirred for 2 h at an ambient temperature.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08053431B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-4aef90640e954669b32defdc816928ed |
| Source note | uspto-grants-2011_11 |