反应详情

A procedure similar to that described in Preparation 43 was repeated, except that 7.50 g of 3-amino-6-benzyloxy-2-methylaminopyridine (prepared as described in Preparation 93) and 7.46 g of glycolic acid were reacted. After working up the product as described in Preparation 43 , the resulting crude product was purifying by column chromatography through silica gel, using a 10:1 by volume mixture of ethyl acetate and methanol as the eluent, and was then crystallized by trituration with ethyl acetate, to give 4.10 g of the title compound, melting at 133°-135° C.

1. customA procedure similar to that described in Preparation 43
2. customwere reacted
3. customas described in Preparation 43
4. customthe resulting crude product was purifying by column chromatography through silica gel
5. additionby volume mixture of ethyl acetate and methanol as the eluent
6. customwas then crystallized by trituration with ethyl acetate