反应详情

温度

60 °C

A solution of 6.30 g of 5-{4-[2-(1,3-dioxolan-2-yl) ethoxy]benzyl}thiazolidine-2,4-dione (prepared as described in Preparation 106) in 50 ml of a 4:1 mixture of acetic acid and water was stirred at 60° C. for 6 hours. At the end of this time, the reaction mixture was freed from the solvent by distillation under reduced pressure. The resulting residue was purified by column chromatography through silica gel, using a 1:1 by volume mixture of hexane and ethyl acetate as the eluent, to give 2.20 g of the title compound, melting at 48°-51° C.

1. distillationAt the end of this time, the reaction mixture was freed from the solvent by distillation under reduced pressure
2. customThe resulting residue was purified by column chromatography through silica gel
3. additionby volume mixture of hexane and ethyl acetate as the eluent