Acetic Acid → 5-[4-(3-Oxopropoxy)benzyl]thiazolidine-2,4-dione

Participants

Reaction Conditions

Reaction Steps

A solution of 6.30 g of 5-{4-[2-(1,3-dioxolan-2-yl) ethoxy]benzyl}thiazolidine-2,4-dione (prepared as described in Preparation 106) in 50 ml of a 4:1 mixture of acetic acid and water was stirred at 60° C. for 6 hours. At the end of this time, the reaction mixture was freed from the solvent by distillation under reduced pressure. The resulting residue was purified by column chromatography through silica gel, using a 1:1 by volume mixture of hexane and ethyl acetate as the eluent, to give 2.20 g of the title compound, melting at 48°-51° C.

Provenance & Evidence