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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 555480Generated: October 26, 2026

4-Dimethylamino-1-naphthaldehyde → 2-(4-(Dimethylamino)naphthalen-1-yl)-5,7-dimethoxyquinazolin-4(3H)-one

https://huagongshe.com/reaction/555480

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Dimethylamino-1-naphthaldehydeHCID 608052—
Reactant2-Amino-4,6-dimethoxybenzamideHCID 20349016—
Reactant5,7-dimethoxy-2-(pyridin-2-yl)quinazolin-4(3H)-oneHCID 136037998—
Product2-(4-(Dimethylamino)naphthalen-1-yl)-5,7-dimethoxyquinazolin-4(3H)-oneHCID 13603797526%

Reaction Steps

2-(4-(Dimethylamino)naphthalen-1-yl)-5,7-dimethoxyquinazolin-4(3H)-one was synthesized from 2-amino-4,6-dimethoxybenzamide and 4-dimethylamino-1-naphthaldehyde, using the method described for 5,7-dimethoxy-2-(pyridin-2-yl)quinazolin-4(3H)-one. 2-(4-(Dimethylamino)naphthalen-1-yl)-5,7-dimethoxyquinazolin-4(3H)-one (75 mg, 26%) was isolated as a yellow solid. Selected data: MS (m/z): 376.07; MP 269-271° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08053440B2
Source datasetuspto-grants-2011_11
ORD IDord-b6caa728bcf641ed8971a9db8a24cc66
Source noteuspto-grants-2011_11