HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium borohydride → (S)-tert-Butyl 4-((tert-butoxycarbonyl)amino)-5-hydroxypentanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium borohydride | HCID 4148881 | — |
| Reactant | (4S)-5-(tert-butoxy)-4-{[(tert-butoxy)carbonyl]amino}-5-oxopentanoic acid | HCID 6993444 | — |
| Reactant | Z-Glu-OtBu | HCID 6994036 | — |
| Product | (S)-tert-Butyl 4-((tert-butoxycarbonyl)amino)-5-hydroxypentanoate | HCID 4055117 | — |
Reaction Steps
Cbz-Glu-OtBu 51 is converted to 52 via the methyl ester followed by LiBH4 reduction according to the procedure of Y. Hamada, M. Shibata, T. Sugiura, S. Kato and T. Shioiri, J. Org. Chem.52:1242, 1987 used for the conversion of t-Boc-Glu-OtBu to the corresponding alcohol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05625075 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-be541d90fafe46f8b47c768145e1a350 |
| Source note | uspto-grants-1997_04 |