Hydrochloric Acid → HCID 178433888, compound

HRID 555614Notes

Reaction equation

HRID 555614 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[C:15](=[O:16])[C:14](=[C:17]([NH:19][NH:20][C:21]([C:23]3[S:24][C:25]([C:28]([O:30]C)=[O:29])=[CH:26][CH:27]=3)=[O:22])[CH3:18])[C:13]([CH3:32])=[N:12]2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+].Cl>CO>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([N:11]2[C:15](=[O:16])[C:14](=[C:17]([NH:19][NH:20][C:21]([C:23]3[S:24][C:25]([C:28]([OH:30])=[O:29])=[CH:26][CH:27]=3)=[O:22])[CH3:18])[C:13]([CH3:32])=[N:12]2)=[CH:9][CH:10]=1)([CH3:2])([CH3:3])[CH3:4]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178498003HCID 178498003, compound

Product 1

HCID 178433888HCID 178433888, compoundYield 47%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

14.9 mg (0.033 mmol) of 5-methoxycarbonyl-2-thiophenecarboxylic acid N′-(1-(1-(4-tert-butylphenyl)-3-methyl-5-oxo-1,5-dihydropyrazol-4-ylidene)-ethyl)-hydrazide in 1.5 mL of methanol was stirred with 164 μL (0.164 mmol) of 1M aqueous sodium hydroxide at room temperature for 17 hours. After the stirring, 164 μL (0.164 mmol) of 1M hydrochloric acid was added, and the precipitated solid was collected by filtration to obtain 6.8 mg of the desired product as a pale yellow solid (yield 47%).

Workup

  1. filtrationthe precipitated solid was collected by filtration

Sources & evidence

ORD record
ord-c3320b4241e744fabc3589e047a99833
Source dataset
uspto-grants-2011_11
Patent number
US08053453B2

Reaction notes

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