Hydrochloric Acid → HCID 178433851, compound

HRID 555616Notes

Reaction equation

HRID 555616 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[N:11]1[C:15](=[O:16])[C:14](=[C:17]([NH:19][NH:20][C:21](=[O:32])[C:22]2[CH:27]=[CH:26][C:25]([C:28]([O:30]C)=[O:29])=[CH:24][CH:23]=2)[CH3:18])[C:13]([CH3:33])=[N:12]1.[OH-].[Na+].Cl>CO>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[N:11]1[C:15](=[O:16])[C:14](=[C:17]([NH:19][NH:20][C:21](=[O:32])[C:22]2[CH:23]=[CH:24][C:25]([C:28]([OH:30])=[O:29])=[CH:26][CH:27]=2)[CH3:18])[C:13]([CH3:33])=[N:12]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178497998HCID 178497998, compound

Product 1

HCID 178433851HCID 178433851, compoundYield 34%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1.5 mL of a methanol solution of 14.9 mg (0.034 mmol) of the 4-methoxycarbonylbenzoic N′-(1-(1-(quinolin-2-yl)-3-methyl-5-oxo-1,5-dihydropyrazol-4-ylidene)-ethyl)-hydrazide synthesized in 1) was stirred with 168 μL (0.168 mmol) of 1M aqueous sodium hydroxide at 50° C. for 12 hours. After the stirring, 168 μL (0.168 mmol) of 1M hydrochloric acid was added, and the precipitated solid was collected by filtration to obtain 4.9 mg of the desired product as a dark yellow solid (yield 34%).

Workup

  1. filtrationthe precipitated solid was collected by filtration

Sources & evidence

ORD record
ord-95beca59f22f422296859aaa9431dacc
Source dataset
uspto-grants-2011_11
Patent number
US08053453B2

Reaction notes

Loading…