Trifluoroacetic acid → HCID 178422832, compound

HRID 555632Notes

Reaction equation

HRID 555632 reaction equation
C(OC([N:8]1[C:12]([C:13]2[C:14](=[O:26])[N:15]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[N:16]([CH3:19])[C:17]=2[CH3:18])=[CH:11][C:10]([CH3:27])=[N:9]1)=O)(C)(C)C.C(OC(N1C(C)=CC(C2C(=O)N(C3C=CC=CC=3)N(C)C=2C)=N1)=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[CH3:27][C:10]1[CH:11]=[C:12]([C:13]2[C:14](=[O:26])[N:15]([C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)[N:16]([CH3:19])[C:17]=2[CH3:18])[NH:8][N:9]=1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 59707162HCID 59707162, compoundHCID 59707172HCID 59707172, compound

Product 1

HCID 178422832HCID 178422832, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To the mixture of the N-methyl isomers (E) and (F) of Example 26 (0.012 g, 0.035 mmol) in dichloromethane (1 ml) add trifluoroacetic acid (1 ml). Stir this mixture at room temperature for 1 hour, and then evaporate the mixture to dryness. Dilute the residue with dichloromethane, wash sequentially with water, aqueous sodium bicarbonate solution, and water. Dry the organic layer (sodium sulfate) and concentrate to give 0.009 g (0.035 mmol) of the title compound.

Workup

  1. customevaporate the mixture to dryness
  2. additionDilute the residue with dichloromethane
  3. washwash sequentially with water, aqueous sodium bicarbonate solution, and water
  4. dry with materialDry the organic layer (sodium sulfate)
  5. concentrationconcentrate

Sources & evidence

ORD record
ord-34ab6c19d3a343f5ad12e9dfb3c16936
Source dataset
uspto-grants-2011_11
Patent number
US08053458B2

Reaction notes

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