2-Methoxyethanol → HCID 63083697, compound

HRID 555713Notes

Reaction equation

HRID 555713 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4](F)[CH:3]=1.[CH3:11][O:12][CH2:13][CH2:14][OH:15]>>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][NH2:7])=[C:4]([O:15][CH2:14][CH2:13][O:12][CH3:11])[CH:3]=1

Participants

3

Reactant 2

HCID 80192-MethoxyethanolHCID 936554-Chloro-2-fluorobenzonitrile

Product 1

HCID 63083697HCID 63083697, compound

Procedure

The title compound is synthesized by coupling followed by reduction of 4-chloro-2-fluoro-benzonitrile and 2-methoxy-ethanol analogously to the preparation of Intermediate 98.1 as a colorless solid; ES-MS: M+=216.1; HPLC: AtRet=2.51 min.

Workup

  1. customAtRet=2.51 min.

Sources & evidence

ORD record
ord-de468276ba744d84ad9e07fa42c4b6a1
Source dataset
uspto-grants-2011_11
Patent number
US08053457B2

Reaction notes

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