3-Methoxy-1-propanol → HCID 63081121, compound

HRID 555714Notes

Reaction equation

HRID 555714 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4](F)[CH:3]=1.[CH3:11][O:12][CH2:13][CH2:14][CH2:15][OH:16]>>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][NH2:7])=[C:4]([O:16][CH2:15][CH2:14][CH2:13][O:12][CH3:11])[CH:3]=1

Participants

3

Reactant 2

HCID 741163-Methoxy-1-propanolHCID 936554-Chloro-2-fluorobenzonitrile

Product 1

HCID 63081121HCID 63081121, compound

Procedure

The title compound is synthesized by coupling followed by reduction of 4-chloro-2-fluoro-benzonitrile and 3-methoxy-propanol analogously to the preparation of Intermediate 98.1 as a colorless solid; ES-MS: M+=230.1; HPLC: AtRet=2.81 min.

Workup

  1. customAtRet=2.81 min.

Sources & evidence

ORD record
ord-bd3837aa46f944a6a5b26c260025d738
Source dataset
uspto-grants-2011_11
Patent number
US08053457B2

Reaction notes

Loading…