1,3-Propanediol → HCID 63082662, compound

HRID 555717Notes

Reaction equation

HRID 555717 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4](F)[CH:3]=1.[CH2:11]([OH:15])[CH2:12][CH2:13][OH:14]>>[NH2:7][CH2:6][C:5]1[CH:8]=[CH:9][C:2]([Cl:1])=[CH:3][C:4]=1[O:14][CH2:13][CH2:12][CH2:11][OH:15]

Participants

3

Reactant 2

HCID 104421,3-PropanediolHCID 936554-Chloro-2-fluorobenzonitrile

Product 1

HCID 63082662HCID 63082662, compound

Procedure

The title compound is synthesized by coupling followed by reduction of 4-chloro-2-fluoro-benzonitrile and 1,3-propane-diol analogously to the preparation of Intermediate 113.1 as a colorless solid; ES-MS: M+=216.1; HPLC: AtRet=2.23 min.

Workup

  1. customAtRet=2.23 min.

Sources & evidence

ORD record
ord-f16fac01b4504fb3a3d9837a2bad6463
Source dataset
uspto-grants-2011_11
Patent number
US08053457B2

Reaction notes

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