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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 555735Generated: October 25, 2026

Bromoacetonitrile → [4-(3-Methoxy-propyl)-piperazin-1-yl]acetonitrile

https://huagongshe.com/reaction/555735

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBromoacetonitrileHCID 11534—
Reactant1-(3-Methoxypropyl)piperazineHCID 1822536—
Product[4-(3-Methoxy-propyl)-piperazin-1-yl]acetonitrileHCID 63337188—

Reaction Steps

The title compound is synthesized by coupling of 1-(3-Methoxy-propyl)-piperazine (commercially available from CHESS GmbH) and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless oil; ES-MS: M+=198.2: 1HNMR(DMSO-d6) 3.65 (s, 2H), 3.30 (s, 3H), 2.45-2.20 (m, 12H), 1.65-1.55 (m, 2H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08053457B2
Source datasetuspto-grants-2011_11
ORD IDord-5a961d53f151413babf4cc3829fa4668
Source noteuspto-grants-2011_11