Bromoacetonitrile → HCID 63337452, compound

HRID 555736Notes

Reaction equation

HRID 555736 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)=[CH:3][CH:2]=1.Br[CH2:14][C:15]#[N:16]>>[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:8][CH2:9][N:10]([CH2:14][C:15]#[N:16])[CH2:11][CH2:12]2)=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 11534BromoacetonitrileHCID 705171-(4-Pyridyl)piperazine

Product 1

HCID 63337452HCID 63337452, compound

Procedure

The title compound is synthesized by coupling of 1-Pyridin-4-yl-piperazine and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless oil; ES-MS: M+=202.2: 1HNMR(DMSO-d6) 8.15 (d, 2H), 6.80 (d, 2H), 3.80 (s, 1H), 3.35 (t, 4H), 2.50 (t, 4H).

Sources & evidence

ORD record
ord-1ae52da77862428493473a7a2d39a8de
Source dataset
uspto-grants-2011_11
Patent number
US08053457B2

Reaction notes

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