HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromoacetonitrile → 4-(2-Pyridinyl)-1-piperazineacetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromoacetonitrile | HCID 11534 | — |
| Reactant | 1-(2-Pyridyl)piperazine | HCID 94459 | — |
| Product | 4-(2-Pyridinyl)-1-piperazineacetonitrile | HCID 22688901 | — |
Reaction Steps
The title compound is synthesized by coupling of 1-Pyridin-2-yl-piperazine and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless oil; ES-MS: M+=203.2: 1HNMR(DMSO-d6) 8.05 (dd, 1H), 7.50 (dd, 1H), 6.80 (d, 1H), 6.60 (dd, 1H), 3.80 (s, 1H), 3.50 (t, 4H), 2.50 (t, 4H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08053457B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-4f689679afb2420784ab878057dc44bc |
| Source note | uspto-grants-2011_11 |