Bromoacetonitrile → 4-(2-Pyridinyl)-1-piperazineacetonitrile

HRID 555739Notes

Reaction equation

HRID 555739 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.Br[CH2:14][C:15]#[N:16]>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]1[CH2:8][CH2:9][N:10]([CH2:14][C:15]#[N:16])[CH2:11][CH2:12]1

Participants

3

Reactant 2

HCID 11534BromoacetonitrileHCID 944591-(2-Pyridyl)piperazine

Product 1

HCID 226889014-(2-Pyridinyl)-1-piperazineacetonitrile

Procedure

The title compound is synthesized by coupling of 1-Pyridin-2-yl-piperazine and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless oil; ES-MS: M+=203.2: 1HNMR(DMSO-d6) 8.05 (dd, 1H), 7.50 (dd, 1H), 6.80 (d, 1H), 6.60 (dd, 1H), 3.80 (s, 1H), 3.50 (t, 4H), 2.50 (t, 4H).

Sources & evidence

ORD record
ord-4f689679afb2420784ab878057dc44bc
Source dataset
uspto-grants-2011_11
Patent number
US08053457B2

Reaction notes

Loading…