Bromoacetonitrile → 2-(4-Benzylpiperazin-1-yl)acetonitrile

HRID 555740Notes

Reaction equation

[CH2:1]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:15][C:16]#[N:17]>>[CH2:1]([N:8]1[CH2:13][CH2:12][N:11]([CH2:15][C:16]#[N:17])[CH2:10][CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 11534Bromoacetonitrile

HCID 759941-Benzylpiperazine

Product 1

HCID 38557212-(4-Benzylpiperazin-1-yl)acetonitrile

Procedure

The title compound is synthesized by coupling of 1-Benzyl-piperazine and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a white solid; ES-MS: M+=216.2: AtRet=1.50.

Sources & evidence

ORD record: ord-95091fe7372a44b8a90fa6737f844031
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08053457B2

Reaction notes

Loading…