Bromoacetonitrile → (4-Cyclopentyl-piperazin-1-yl)-acetonitrile

HRID 555744Notes

Reaction equation

HRID 555744 reaction equation
[CH:1]1([N:6]2[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.Br[CH2:13][C:14]#[N:15]>>[CH:1]1([N:6]2[CH2:7][CH2:8][N:9]([CH2:13][C:14]#[N:15])[CH2:10][CH2:11]2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

3

Reactant 2

HCID 11534BromoacetonitrileHCID 8064211-Cyclopentylpiperazine

Product 1

HCID 60750841(4-Cyclopentyl-piperazin-1-yl)-acetonitrile

Procedure

The title compound is synthesized by coupling of 1-Cyclopentyl-piperazine (commercially available from CHESS GmbH) and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless oil; ES-MS: M+=194.2: 1HNMR(DMSO-d6) 3.65 (s, 2H), 2.45-2.20 (m, 9H), 1.80-1.20 (m, 8H).

Workup

  1. customanalogously to the preparation of Intermediate 149.2 as a colorless oil

Sources & evidence

ORD record
ord-9c080a3a1b2a4b4b9f6eb6ed27ac5cf5
Source dataset
uspto-grants-2011_11
Patent number
US08053457B2

Reaction notes

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