Bromoacetonitrile → HCID 61951591, compound

HRID 555745Notes

Reaction equation

HRID 555745 reaction equation
[NH:1]1CCN[CH2:3][CH2:2]1.[CH:7]1([CH2:13][N:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1.BrCC#N>>[CH:7]1([CH2:13][N:14]2[CH2:15][CH2:16][N:17]([CH2:3][C:2]#[N:1])[CH2:18][CH2:19]2)[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12]1

Participants

3

Reactant 2

HCID 11534BromoacetonitrileHCID 66986907HCID 66986907, compound

Product 1

HCID 61951591HCID 61951591, compound

Procedure

The title compound is synthesized by coupling of 1-Cyclohexylmethyl-piperazine piperazine (commercially available from Fluorochem Ltd) and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless oil; ES-MS: M+=222.2: 1HNMR(DMSO-d6) 3.65 (s, 2H), 2.45-2.20 (m, 8H), 2.00 (d, 2H), 1.70-1.55 (m, 5H), 1.50-1.40 (m, 1H), 1.20-1.05 (m, 3H), 0.85-0.70 (m, 2H).

Workup

  1. customanalogously to the preparation of Intermediate 149.2 as a colorless oil

Sources & evidence

ORD record
ord-7182e7cf9c004415b3b42cb277f74b23
Source dataset
uspto-grants-2011_11
Patent number
US08053457B2

Reaction notes

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