Bromoacetonitrile → HCID 86641788, compound

HRID 555746Notes

Reaction equation

[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH2:12][CH2:11][O:10][CH2:9][CH2:8]2)[CH2:3][CH2:2]1.Br[CH2:14][C:15]#[N:16]>>[N:7]1([CH:4]2[CH2:5][CH2:6][N:1]([CH2:14][C:15]#[N:16])[CH2:2][CH2:3]2)[CH2:12][CH2:11][O:10][CH2:9][CH2:8]1

Participants

Reactant 2

HCID 11534Bromoacetonitrile

HCID 7957244-Morpholinopiperidine

Product 1

HCID 86641788HCID 86641788, compound

Procedure

The title compound is synthesized by coupling of 4-Piperidin-4-yl-morpholine (commercially available from CHESS GmbH) and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless oil; ES-MS: M+=210.1: 1HNMR(DMSO-d6) 3.65 (s, 2H), 3.55 (t, 4H), 2.80-2.75 (m, 2H), 2.40 (t, 4H), 2.15-2.00 (m, 3H), 1.80-1.70 (m, 2H), 1.40-1.30 (m, 2H).

Workup

customanalogously to the preparation of Intermediate 149.2 as a colorless oil

Sources & evidence

ORD record: ord-3096b66636b5464b9b6db85fb81da4ab
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08053457B2

Reaction notes

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