Bromoacetonitrile → HCID 86641789, compound

HRID 555748Notes

Reaction equation

HRID 555748 reaction equation
[N:1]1([CH:6]2[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.Br[CH2:13][C:14]#[N:15]>>[N:1]1([CH:6]2[CH2:11][CH2:10][N:9]([CH2:13][C:14]#[N:15])[CH2:8][CH2:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 11534BromoacetonitrileHCID 787034-(1-Pyrrolidinyl)piperidine

Product 1

HCID 86641789HCID 86641789, compound

Procedure

The title compound is synthesized by coupling of 4-Pyrrolidin-1-yl-piperidine (commercially available from CHESS GmbH) and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a white solid; ES-MS: M+=194.1: 1HNMR(DMSO-d6) 3.65 (s, 2H), 2.75-2.70 (m, 2H), 2.45-2.40 (m, 4H), 2.20-2.10 (m, 2H), 1.90-1.75 (m, 3H), 1.65-1.60 (m, 4H), 1.45-1.30 (m, 2H).

Workup

  1. customanalogously to the preparation of Intermediate 149.2 as a white solid

Sources & evidence

ORD record
ord-89d57211dbe543e3aefbc270fb639470
Source dataset
uspto-grants-2011_11
Patent number
US08053457B2

Reaction notes

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