Bromoacetonitrile → (4-Pyridin-4-ylmethyl-piperazin-1-yl)-acetonitrile

HRID 555750Notes

Reaction equation

HRID 555750 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:3][CH:2]=1.Br[CH2:15][C:16]#[N:17]>>[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][N:8]2[CH2:13][CH2:12][N:11]([CH2:15][C:16]#[N:17])[CH2:10][CH2:9]2)=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 11534BromoacetonitrileHCID 8087151-((Pyridin-4-yl)methyl)piperazine

Product 1

HCID 63337270(4-Pyridin-4-ylmethyl-piperazin-1-yl)-acetonitrile

Procedure

The title compound is synthesized by coupling of 1-Pyridin-4-ylmethyl-piperazine (commercially available from ABCR GmbH) and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless oil; ES-MS: M+=217.2: 1HNMR(CDCl3) 8.55 (d, 2H), 7.25 (d, 2H), 3.50 (s, 4H), 2.70-2.40 (m, 8H).

Workup

  1. customanalogously to the preparation of Intermediate 149.2 as a colorless oil

Sources & evidence

ORD record
ord-4257399ccb734528a88461f5610ed262
Source dataset
uspto-grants-2011_11
Patent number
US08053457B2

Reaction notes

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