Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 555750Generated: October 26, 2026

Bromoacetonitrile → (4-Pyridin-4-ylmethyl-piperazin-1-yl)-acetonitrile

https://huagongshe.com/reaction/555750

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBromoacetonitrileHCID 11534—
Reactant1-((Pyridin-4-yl)methyl)piperazineHCID 808715—
Product(4-Pyridin-4-ylmethyl-piperazin-1-yl)-acetonitrileHCID 63337270—

Reaction Steps

The title compound is synthesized by coupling of 1-Pyridin-4-ylmethyl-piperazine (commercially available from ABCR GmbH) and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless oil; ES-MS: M+=217.2: 1HNMR(CDCl3) 8.55 (d, 2H), 7.25 (d, 2H), 3.50 (s, 4H), 2.70-2.40 (m, 8H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08053457B2
Source datasetuspto-grants-2011_11
ORD IDord-4257399ccb734528a88461f5610ed262
Source noteuspto-grants-2011_11