Bromoacetonitrile → HCID 43430780, compound

HRID 555754Notes

Reaction equation

HRID 555754 reaction equation
[CH3:1][N:2]([CH3:9])[CH:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1.Br[CH2:11][C:12]#[N:13]>>[CH3:1][N:2]([CH3:9])[CH:3]1[CH2:8][CH2:7][N:6]([CH2:11][C:12]#[N:13])[CH2:5][CH2:4]1

Participants

3

Reactant 2

HCID 11534BromoacetonitrileHCID 417391N,N-Dimethylpiperidin-4-amine

Product 1

HCID 43430780HCID 43430780, compound

Procedure

The title compound is synthesized by coupling of Dimethyl-piperidin-4-yl-amine and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless oil; ES-MS: M+=168.1: 1HNMR(DMSO-d6) 3.65 (s, 2H), 2.80-2.75 (m, 2H), 2.15-2.05 (m, 8H, including a singlet at 2.10), 2.00-1.95 (m, 1H), 1.75-1.65 (m, 2H), 1.40-1.30 (m, 2H).

Sources & evidence

ORD record
ord-6d3d3d894d27443d8a39d5041de8edb1
Source dataset
uspto-grants-2011_11
Patent number
US08053457B2

Reaction notes

Loading…