HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromoacetonitrile → (4-Diethylamino-piperidin-1-yl)-acetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromoacetonitrile | HCID 11534 | — |
| Reactant | N,N-diethylpiperidin-4-amine | HCID 2758239 | — |
| Product | (4-Diethylamino-piperidin-1-yl)-acetonitrile | HCID 86641790 | — |
Reaction Steps
The title compound is synthesized by coupling of Diethyl-piperidin-4-yl-amine (commercially available from CHESS GmbH) and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless oil; ES-MS: M+=196.2: 1HNMR(DMSO-d6) 3.65 (s, 2H), 2.80-2.75 (m, 2H), 2.45-2.30 (m, 5H), 2.15-2.05 (m, 2H), 1.70-1.60 (m, 2H), 1.45-1.35 (m, 2H), 0.95 (t, 6H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08053457B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-73dda83f8ae345bea50e786e1868cdcb |
| Source note | uspto-grants-2011_11 |