Bromoacetonitrile → (4-Indan-1-yl-piperazin-1-yl)-acetonitrile

HRID 555770Notes

Reaction equation

HRID 555770 reaction equation
[CH:1]1([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.Br[CH2:17][C:18]#[N:19]>>[CH:1]1([N:10]2[CH2:15][CH2:14][N:13]([CH2:17][C:18]#[N:19])[CH2:12][CH2:11]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 11534BromoacetonitrileHCID 108458021-Indan-1-yl-piperazine

Product 1

HCID 86641798(4-Indan-1-yl-piperazin-1-yl)-acetonitrile

Procedure

The title compound is synthesized by coupling of 1-Indan-1-yl-piperazine (commercially available from CHESS GmbH) and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless oil; ES-MS: M+H=242.2: CtRet=4.25.

Workup

  1. customanalogously to the preparation of Intermediate 149.2 as a colorless oil

Sources & evidence

ORD record
ord-4e927e96c23c49c6ae3fdb6766f989c0
Source dataset
uspto-grants-2011_11
Patent number
US08053457B2

Reaction notes

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