Bromoacetonitrile → [4-(2-Morpholin-4-yl-ethyl)-piperazin-1-yl]-acetonitrile

Participants

Role	Name	HCID	Charge
Reactant	Bromoacetonitrile	HCID 11534	—
Reactant	4-(2-Piperazin-1-yl-ethyl)-morpholine	HCID 2734640	—
Product	[4-(2-Morpholin-4-yl-ethyl)-piperazin-1-yl]-acetonitrile	HCID 63336725	—

Reaction Steps

The title compound is synthesized by coupling of 4-(2-piperazin-1-yl-ethyl)-morpholine (commercially available from ABCR GmbH) and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless oil; ES-MS: M+H=239.3; 1HNMR(DMSO-d6) 3.70 (s, 2H), 3.30 (bs, 4H), 2.60-2.30 (m, 16H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08053457B2
Source dataset	uspto-grants-2011_11
ORD ID	ord-33b1524a60bd41bea960f81682eb4fc5
Source note	uspto-grants-2011_11