Bromoacetonitrile → (4-Phenethyl-piperazin-1-yl)-acetonitrile

HRID 555776Notes

Reaction equation

HRID 555776 reaction equation
[C:1]1([CH2:7][CH2:8][N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[CH2:16][C:17]#[N:18]>>[CH2:8]([N:9]1[CH2:10][CH2:11][N:12]([CH2:16][C:17]#[N:18])[CH2:13][CH2:14]1)[CH2:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 11534BromoacetonitrileHCID 792141-Phenethylpiperazine

Product 1

HCID 55026723(4-Phenethyl-piperazin-1-yl)-acetonitrile

Procedure

The title compound is synthesized by coupling of 4-Phenylethyl-piperazine (commercially available from ABCR GmbH) and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless oil; ES-MS: M+H=230.2: CtRet=4.20.

Workup

  1. customanalogously to the preparation of Intermediate 149.2 as a colorless oil

Sources & evidence

ORD record
ord-21817461be514e7eafe8ee03d669d6e8
Source dataset
uspto-grants-2011_11
Patent number
US08053457B2

Reaction notes

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