反应详情

A mixture of 5-Chloro-2-cyanopyridine (1.5 g, 10.8 mmol) and 10% Pd/C (0.4 g) in EtOH (40 mL) and conc HCl (1.2 mL) is shaken under a H2-atmosphere (1 bar). After 2 h, the reaction mixture is filtered through Celite and carefully washed with THF. Concentration in vacuo and silica gel flash chromatography of the residue affords the title compound as a white solid; ES-MS: M+H=143.0: CtRet=3.33.

1. filtrationthe reaction mixture is filtered through Celite
2. washcarefully washed with THF
3. concentrationConcentration in vacuo and silica gel flash chromatography of the residue