N-(tert-butoxycarbonyl)glycine → HCID 66987183, compound

HRID 555783Notes

Reaction equation

HRID 555783 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:2]=1.[C:14]([NH:21][CH2:22][C:23](O)=[O:24])([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15]>>[C:17]([O:16][C:14](=[O:15])[NH:21][CH2:22][C:23](=[O:24])[N:11]1[CH2:12][CH2:13][N:8]([CH2:7][C:3]2[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=2)[CH2:9][CH2:10]1)([CH3:20])([CH3:18])[CH3:19]

Participants

3

Reactant 2

HCID 78288N-(tert-butoxycarbonyl)glycineHCID 1569751-[(Pyridin-3-yl)methyl]piperazine

Product 1

HCID 66987183HCID 66987183, compound

Procedure

The title compound is synthesized by condensation of 1-Pyridin-3-ylmethyl-piperazine and N-Boc-glycine analogously to the preparation of Example 2 as a colorless solid; ES-MS: M+H=335.3; HPLC: AtRet=3.93 min.

Workup

  1. customAtRet=3.93 min.

Sources & evidence

ORD record
ord-8ea9beed000946008f5afbff18e63af1
Source dataset
uspto-grants-2011_11
Patent number
US08053457B2

Reaction notes

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