Pivalaldehyde → HCID 16748909, compound

HRID 555788Notes

Reaction equation

HRID 555788 reaction equation
[C:1]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[CH:14](=O)[C:15]([CH3:18])([CH3:17])[CH3:16]>C(Cl)Cl.CCOC(C)=O>[C:4]([O:3][C:1]([N:8]1[CH2:9][CH2:10][N:11]([CH2:14][C:15]([CH3:18])([CH3:17])[CH3:16])[CH2:12][CH2:13]1)=[O:2])([CH3:7])([CH3:6])[CH3:5]

Participants

4

Reactant 2

HCID 12417PivalaldehydeHCID 143452tert-Butyl piperazine-1-carboxylate

Product 1

HCID 16748909HCID 16748909, compound

Reagents, catalysts & solvents 1

HCID 21226138Dichloromethane ethylacetateSolvent

Procedure

The title compound is synthesized by reductive amination of 1-Boc-piperazine and Pivalaldehyde analogously to the preparation of Example 233 as a colorless oil; ES-MS: M+H=257.3; TLC: Rf=0.82 (DCM/EtOAc=4:1).

Sources & evidence

ORD record
ord-f96fdcfa13c14e23a06156d34a1ff251
Source dataset
uspto-grants-2011_11
Patent number
US08053457B2

Reaction notes

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