Cyclopentanecarbaldehyde → HCID 58334374, compound

HRID 555789Notes

Reaction equation

HRID 555789 reaction equation
[C:1]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[CH:14]1([CH:19]=O)[CH2:18][CH2:17][CH2:16][CH2:15]1>C(Cl)Cl.CCOC(C)=O>[C:4]([O:3][C:1]([N:8]1[CH2:9][CH2:10][N:11]([CH2:19][CH:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)[CH2:12][CH2:13]1)=[O:2])([CH3:7])([CH3:6])[CH3:5]

Participants

4

Reactant 2

HCID 70106CyclopentanecarbaldehydeHCID 143452tert-Butyl piperazine-1-carboxylate

Product 1

HCID 58334374HCID 58334374, compound

Reagents, catalysts & solvents 1

HCID 21226138Dichloromethane ethylacetateSolvent

Procedure

The title compound is synthesized by reductive amination of 1-Boc-piperazine and Cyclopentane-carboaldehyde analogously to the preparation of Example 233 as a colorless oil; ES-MS: M+H=269.2; TLC: Rf=0.45 (DCM/EtOAc=1:1).

Sources & evidence

ORD record
ord-3ae209c81e4a45febc439c2dd4ec5e06
Source dataset
uspto-grants-2011_11
Patent number
US08053457B2

Reaction notes

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