Trifluoroacetic acid → N-methoxy-N-methylpiperidine-4-carboxamide
Reaction equation
[CH3:1][O:2][N:3]([CH3:19])[C:4]([CH:6]1[CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH2:7]1)=[O:5].FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:1][O:2][N:3]([CH3:19])[C:4]([CH:6]1[CH2:7][CH2:8][NH:9][CH2:10][CH2:11]1)=[O:5]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 27.5 °C
Procedure
To a solution of tert-butyl 4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate (50 g, 182 mmol) in DCM (400 mL) was added trifluoroacetic acid (150 mL) and the resulting mixture was stirred for 6 h at 25-30° C. After completion of the reaction, the solvent was removed under reduced pressure to afford 40 g of N-methoxy-N-methylpiperidine-4-carboxamide product. [M+1]=173.04
Workup
- customAfter completion of the reaction
- customthe solvent was removed under reduced pressure
Sources & evidence
- ORD record
- ord-29c642dabfaa423f8af103898b63a339
- Source dataset
- uspto-grants-2011_11
- Patent number
- US08053438B2
Reaction notes
Loading…