反应详情

Aminoguanidine (2.450 g, 2.21 mmol) is added to a solution of 1,2-bis(4-methoxyphenyl)-ethane-1,2-dione prepared according to example 1 (5 g, 18.5 mmol) in ethanol (50 ml). The mixture is heated at reflux for 12 hours. After returning to ambient temperature, the precipitate obtained is filtered, washed with ethanol and is dried to yield a yellow solid. The residue is purified by chromatography on a silica gel (dichloromethane/triethylamine 0.5%) to yield 3.7 g (65%) of a yellow solid. δH (200 MHz, CDCl3), 3.88 (s; 6H), 5.51 (s; 2H), 6.92 (m; 4H), 7.41 (m; 4H).

1. customprepared
2. temperatureThe mixture is heated
3. temperatureat reflux for 12 hours
4. customAfter returning to ambient temperature
5. customthe precipitate obtained
6. filtrationis filtered
7. washwashed with ethanol
8. customis dried
9. customto yield a yellow solid
10. customThe residue is purified by chromatography on a silica gel (dichloromethane/triethylamine 0.5%)