2-(2-Ethyl-2h-tetrazol-5-yl)-ethylamine → 1-(6-Bromo-imidazo[1,2-a]pyridin-2-yl)-3-[2-(2-ethyl-2h-tetrazol-5-yl)-ethyl]-urea

HRID 555981Notes

Reaction equation

HRID 555981 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([NH:11][C:12]([NH:14][CH2:15][CH2:16][C:17]3[N:18]=[N:19][N:20]([CH:22](C)[CH3:23])[N:21]=3)=[O:13])[N:10]=2)[CH:7]=1.Cl.C(N1N=NC(CCN)=N1)(C)C.C(N1N=NC(CCN)=N1)C>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([NH:11][C:12]([NH:14][CH2:15][CH2:16][C:17]3[N:18]=[N:19][N:20]([CH2:22][CH3:23])[N:21]=3)=[O:13])[N:10]=2)[CH:7]=1

Participants

4

Reactant 3

HCID 552855002-(2-Ethyl-2h-tetrazol-5-yl)-ethylamine2×HCID 592518731-(6-Bromo-imidazo[1,2-a]pyridin-2-yl)-3-[2-(2-isopropyl-2H-tetrazol-5-yl)-ethyl]-ureaHCID 669862432-(2-isopropyl-2H-tetrazol-5-yl)-ethylamine hydrochloride

Product 1

HCID 251744911-(6-Bromo-imidazo[1,2-a]pyridin-2-yl)-3-[2-(2-ethyl-2h-tetrazol-5-yl)-ethyl]-urea

Procedure

This compound is prepared analogously to Intermediate E1 (described in preparation of intermediates section) by replacing 2-(2-isopropyl-2H-tetrazol-5-yl)-ethylamine hydrochloride (Intermediate D1) with 2-(2-ethyl-2H-tetrazol-5-yl)-ethylamine (Intermediate D2).

Sources & evidence

ORD record
ord-3756083e3e7943c4b45912e910617685
Source dataset
uspto-grants-2011_11
Patent number
US08053574B2

Reaction notes

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