HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexane → 6-Hydroxy-benzo[d]isoxazole-3-carboxylic acid (3-trifluoromethyl-phenyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexane | HCID 8058 | — |
| Reactant | 6-Benzyloxy-benzo[d]isoxazole-3-carboxylic acid (3-trifluoromethyl-phenyl)-amide | HCID 66992599 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 6-Hydroxy-benzo[d]isoxazole-3-carboxylic acid (3-trifluoromethyl-phenyl)-amide | HCID 136346627 | — |
Reaction Steps
Hydrogenation of 202 mg (0.49 mMol) 6-benzyloxy-benzo[d]isoxazole-3-carboxylic acid (3-trifluoromethyl-phenyl)-amide dissolved in 6 ml THF in presence of 70 mg Pd/C (10%, Engelhard 4505), filtration, concentration of the filtrate and trituration from hexane gives the title compound: MS: [M−1]=321; TLC(hexane/EtOAc 1:1): Rf=0.51.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08058276B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-631fbb98bc8143a09cfc3d50f09a1d21 |
| Source note | uspto-grants-2011_11 |