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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 556370Generated: October 30, 2026

HCID 86626629, compound → HCID 24763376, compound

https://huagongshe.com/reaction/556370

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 86626629HCID 86626629—
CatalystPalladiumHCID 23938—
SolventTetrahydrofuranHCID 8028—
ProductHCID 24763376HCID 24763376—

Reaction Steps

27 mg (0.064 mMol) 6-(2-Amino-6-chloro-pyrimidin-4-yloxy)-pyrazolo[1,5-a]pyridine-3-carboxylic acid (3-trifluoromethyl-phenyl)-amide are dissolved in 2 ml THF and submitted to hydrogenation over Pd—C (Engelhardt 4045) for 2 h at rt. The reaction mixture is worked up by filtration and concentrated to give the title compound as a white solid: m.p.: 102-104° C.; MS: [M+1]+=415.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08058276B2
Source datasetuspto-grants-2011_11
ORD IDord-be48a65917e64965aa8a26caf7016227
Source noteuspto-grants-2011_11