HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 86626629, compound → HCID 24763376, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 86626629 | HCID 86626629 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 24763376 | HCID 24763376 | — |
Reaction Steps
27 mg (0.064 mMol) 6-(2-Amino-6-chloro-pyrimidin-4-yloxy)-pyrazolo[1,5-a]pyridine-3-carboxylic acid (3-trifluoromethyl-phenyl)-amide are dissolved in 2 ml THF and submitted to hydrogenation over Pd—C (Engelhardt 4045) for 2 h at rt. The reaction mixture is worked up by filtration and concentrated to give the title compound as a white solid: m.p.: 102-104° C.; MS: [M+1]+=415.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08058276B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-be48a65917e64965aa8a26caf7016227 |
| Source note | uspto-grants-2011_11 |