HCID 86626629, compound → HCID 24763376, compound

HRID 556370Notes

Reaction equation

HRID 556370 reaction equation
[F:1][C:2]([F:31])([F:30])[C:3]1[CH:4]=[C:5]([NH:9][C:10]([C:12]2[CH:13]=[N:14][N:15]3[CH:20]=[C:19]([O:21][C:22]4[CH:27]=[C:26](Cl)[N:25]=[C:24]([NH2:29])[N:23]=4)[CH:18]=[CH:17][C:16]=23)=[O:11])[CH:6]=[CH:7][CH:8]=1>C1COCC1.[Pd]>[F:31][C:2]([F:1])([F:30])[C:3]1[CH:4]=[C:5]([NH:9][C:10]([C:12]2[CH:13]=[N:14][N:15]3[CH:20]=[C:19]([O:21][C:22]4[CH:27]=[CH:26][N:25]=[C:24]([NH2:29])[N:23]=4)[CH:18]=[CH:17][C:16]=23)=[O:11])[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 1

HCID 86626629HCID 86626629, compound

Product 1

HCID 24763376HCID 24763376, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

27 mg (0.064 mMol) 6-(2-Amino-6-chloro-pyrimidin-4-yloxy)-pyrazolo[1,5-a]pyridine-3-carboxylic acid (3-trifluoromethyl-phenyl)-amide are dissolved in 2 ml THF and submitted to hydrogenation over Pd—C (Engelhardt 4045) for 2 h at rt. The reaction mixture is worked up by filtration and concentrated to give the title compound as a white solid: m.p.: 102-104° C.; MS: [M+1]+=415.

Workup

  1. filtrationThe reaction mixture is worked up by filtration
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-be48a65917e64965aa8a26caf7016227
Source dataset
uspto-grants-2011_11
Patent number
US08058276B2

Reaction notes

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