Sodium ethoxide → HCID 59755136, compound

HRID 556399Notes

Reaction equation

HRID 556399 reaction equation
Cl[C:2]1[N:3]=[C:4]([N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)[C:5]2[S:21][C:9]3[N:10]=[C:11]([C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=4)[N:12]=[C:13]([CH3:14])[C:8]=3[C:6]=2[N:7]=1.[CH3:28][CH2:29][O-:30].[Na+]>C(O)C>[CH2:29]([O:30][C:2]1[N:3]=[C:4]([N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)[C:5]2[S:21][C:9]3[N:10]=[C:11]([C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=4)[N:12]=[C:13]([CH3:14])[C:8]=3[C:6]=2[N:7]=1)[CH3:28]

Participants

4

Reactant 2

HCID 2723922Sodium ethoxideHCID 59755095HCID 59755095, compound

Product 1

HCID 59755136HCID 59755136, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.30 g (3.3 mmol) 2-chloro-9-methyl-4-piperazin-1-yl-7-phenyl-thieno[2,3-d:4,5-d′]di-pyrimidine and 0.67 g (9.9 mmol) sodium ethylate are refluxed in 30 ml ethanol for 3 h. Thereafter, the solvent is removed and the residue is suspended in some water. The aqueous suspension is extracted with dichloromethane and the solvent is removed. 0.90 g (68%) of the title substance is obtained. ESI-MS [m/z]: 407, melting point: >310° C.

Workup

  1. customThereafter, the solvent is removed
  2. extractionThe aqueous suspension is extracted with dichloromethane
  3. customthe solvent is removed
  4. custom0.90 g (68%) of the title substance is obtained

Sources & evidence

ORD record
ord-49f5f08d447245b1b4f7c80db005d315
Source dataset
uspto-grants-2011_11
Patent number
US08058285B2

Reaction notes

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