Hydrogen Peroxide → HCID 11633519, compound

HRID 556415Notes

Reaction equation

HRID 556415 reaction equation
[CH2:1]([S:3][C:4]1[N:5]=[C:6]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[C:7]2[S:12][C:11]3[N:13]=[C:14]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[CH:15]=[C:16]([CH3:17])[C:10]=3[C:8]=2[N:9]=1)[CH3:2].[OH:30]O>C(O)(=O)C>[CH2:1]([S:3]([C:4]1[N:5]=[C:6]([N:24]2[CH2:25][CH2:26][NH:27][CH2:28][CH2:29]2)[C:7]2[S:12][C:11]3[N:13]=[C:14]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[CH:15]=[C:16]([CH3:17])[C:10]=3[C:8]=2[N:9]=1)=[O:30])[CH3:2]

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 11524621HCID 11524621, compound

Product 1

HCID 11633519HCID 11633519, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

85 mg (0.2 mmol) 2-ethylthio-9-methyl-7-phenyl-4-piperazin-1-yl-pyrido[3′,2′:4,5]-thieno[3,2-d]pyrimidine, 3 ml glacial acetic acid and 0.04 ml hydrogen peroxide (60%) are stirred at room temperature for 48 h. Having removed the solvent, the residue is purified by means of flash chromatography (methanol/dichloromethane 1:20-1:3). 50 mg (57%) of the title substance is obtained. ESI-MS [m/z]: 438, melting point: 165-170° C.

Workup

  1. customHaving removed the solvent
  2. customthe residue is purified by means of flash chromatography (methanol/dichloromethane 1:20-1:3)
  3. custom50 mg (57%) of the title substance is obtained

Sources & evidence

ORD record
ord-9ee6eed07ae649abbaf1cc91af5f6887
Source dataset
uspto-grants-2011_11
Patent number
US08058285B2

Reaction notes

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