3-Isopropylsalicylic acid → Rac-2-[6-chloro-3-(3-chloro-benzyl)-2-oxo-2,3-dihydro-1h-indol-3-yloxy]-3-isopropyl-benzoic acid
Reaction equation
[OH:1][C:2]1[C:10]([CH:11]([CH3:13])[CH3:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].Br[C:15]1([CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[C:29]([Cl:33])[CH:28]=2)[C:23]2[C:18](=[CH:19][C:20]([Cl:24])=[CH:21][CH:22]=2)[NH:17][C:16]1=[O:25].ClC1C=C2C(C(NC3C=C(C=CC=3)C(O)=O)(CC3C=CC=C(Cl)C=3)C(=O)N2)=CC=1>>[Cl:24][C:20]1[CH:19]=[C:18]2[C:23]([C:15]([CH2:26][C:27]3[CH:32]=[CH:31][CH:30]=[C:29]([Cl:33])[CH:28]=3)([O:1][C:2]3[C:10]([CH:11]([CH3:13])[CH3:12])=[CH:9][CH:8]=[CH:7][C:3]=3[C:4]([OH:6])=[O:5])[C:16](=[O:25])[NH:17]2)=[CH:22][CH:21]=1Participants
4
Reactant 3
Product 1
Procedure
From 2-hydroxyl-3-isopropyl benzoic acid and rac-3-bromo-6-chloro-3-(3-chloro-benzyl)-1,3-dihydro-indol-2-one, the title compound was prepared following the similar procedure as rac-3-[6-chloro-3-(3-chloro-benzyl)-2-oxo-2,3-dihydro-1H-indol-3-ylamino]-benzoic acid. MS: [M−H]−=468
Sources & evidence
- ORD record
- ord-46af6bd333b94d4cbe22126b9a53020b
- Source dataset
- uspto-grants-2011_11
- Patent number
- US08058269B2
Reaction notes
Loading…