HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Isopropylsalicylic acid → Rac-2-[6-chloro-3-(3-chloro-benzyl)-2-oxo-2,3-dihydro-1h-indol-3-yloxy]-3-isopropyl-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Isopropylsalicylic acid | HCID 201887 | — |
| Reactant | 3-Bromo-6-chloro-3-(3-chloro-benzyl)-1,3-dihydro-indol-2-one | HCID 57507273 | — |
| Reactant | Rac-3-[6-chloro-3-(3-chloro-benzyl)-2-oxo-2,3-dihydro-1h-indol-3-ylamino]-benzoic acid | HCID 57507310 | — |
| Product | Rac-2-[6-chloro-3-(3-chloro-benzyl)-2-oxo-2,3-dihydro-1h-indol-3-yloxy]-3-isopropyl-benzoic acid | HCID 57479089 | — |
Reaction Steps
From 2-hydroxyl-3-isopropyl benzoic acid and rac-3-bromo-6-chloro-3-(3-chloro-benzyl)-1,3-dihydro-indol-2-one, the title compound was prepared following the similar procedure as rac-3-[6-chloro-3-(3-chloro-benzyl)-2-oxo-2,3-dihydro-1H-indol-3-ylamino]-benzoic acid. MS: [M−H]−=468
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08058269B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-46af6bd333b94d4cbe22126b9a53020b |
| Source note | uspto-grants-2011_11 |