Trifluoroacetic acid → N-[2-(Diethylamino)ethyl]-3-[2-(1-naphthyl)ethoxy]-N-(2-oxoethyl)propanamide
Reaction equation
[CH2:1]([N:3]([CH2:30][CH3:31])[CH2:4][CH2:5][N:6]([CH2:24][CH:25](OC)[O:26]C)[C:7](=[O:23])[CH2:8][CH2:9][O:10][CH2:11][CH2:12][C:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15][CH:14]=1)[CH3:2].FC(F)(F)C(O)=O>C(Cl)Cl>[CH2:30]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][N:6]([CH2:24][CH:25]=[O:26])[C:7](=[O:23])[CH2:8][CH2:9][O:10][CH2:11][CH2:12][C:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15][CH:14]=1)[CH3:31]Participants
4
Procedure
A solution of N-[2-(diethylamino)ethyl]-N-(2,2-dimethoxyethyl)-3-[2-(1-naphthyl)ethoxy]propanamide (93 g) in DCM (270 mL) was treated dropwise at 0° C. with trifluoroacetic acid (270 mL) over 1.5 hours. After the addition the reaction mixture was allowed to warm to room temperature and stirred for a further 1 hour. The reaction mixture was concentrated and the residue poured into aqueous saturated sodium bicarbonate solution (1800 mL, caution). The aqueous mixture was extracted with DCM (4×400 mL) and the combined extracts were dried over magnesium sulphate and concentrated. The residue was used directly in the following reaction.
Workup
- additionAfter the addition the reaction mixture
- concentrationThe reaction mixture was concentrated
- additionthe residue poured into aqueous saturated sodium bicarbonate solution (1800 mL, caution)
- extractionThe aqueous mixture was extracted with DCM (4×400 mL)
- dry with materialthe combined extracts were dried over magnesium sulphate
- concentrationconcentrated
- customThe residue was used directly in the following reaction
Sources & evidence
- ORD record
- ord-0f9d3db6d1d04532b23a615b5ec8bd71
- Source dataset
- uspto-grants-2011_11
- Patent number
- US08058294B2
Reaction notes
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