反应详情

A solution of N-[2-(diethylamino)ethyl]-N-(2,2-dimethoxyethyl)-3-[2-(1-naphthyl)ethoxy]propanamide (93 g) in DCM (270 mL) was treated dropwise at 0° C. with trifluoroacetic acid (270 mL) over 1.5 hours. After the addition the reaction mixture was allowed to warm to room temperature and stirred for a further 1 hour. The reaction mixture was concentrated and the residue poured into aqueous saturated sodium bicarbonate solution (1800 mL, caution). The aqueous mixture was extracted with DCM (4×400 mL) and the combined extracts were dried over magnesium sulphate and concentrated. The residue was used directly in the following reaction.

1. additionAfter the addition the reaction mixture
2. concentrationThe reaction mixture was concentrated
3. additionthe residue poured into aqueous saturated sodium bicarbonate solution (1800 mL, caution)
4. extractionThe aqueous mixture was extracted with DCM (4×400 mL)
5. dry with materialthe combined extracts were dried over magnesium sulphate
6. concentrationconcentrated
7. customThe residue was used directly in the following reaction