4-Chlorobenzaldehyde → 1-[2-Hydroxy-4-carboxydimethylmethyloxyphenyl]-3-[4-chlorophenyl]prop-2-en-1-one

HRID 556751Notes

Reaction equation

[OH:1][C:2]1[C:7]([O:8][CH3:9])=[C:6]([C:10]([O:12]CC)=[O:11])[C:5]([CH3:15])=[C:4]([CH3:16])[C:3]=1[C:17](=[O:35])[CH:18]=[CH:19][C:20]1[CH:25]=[C:24](C(C)(C)C)[C:23](O)=[C:22](C(C)(C)C)[CH:21]=1.[Cl:36]C1C=CC(C=O)=CC=1>>[OH:1][C:2]1[C:7]([O:8][CH3:9])=[C:6]([C:10]([OH:12])=[O:11])[C:5]([CH3:15])=[C:4]([CH3:16])[C:3]=1[C:17](=[O:35])[CH:18]=[CH:19][C:20]1[CH:25]=[CH:24][C:23]([Cl:36])=[CH:22][CH:21]=1

Participants

Reactant 2

HCID 77264-Chlorobenzaldehyde

HCID 865999731-[2-Hydroxy-4-ethoxycarbonyldimethylmethyloxyphenyl]-3-[3,5-ditertbutyl-4-hydroxyphenyl] prop-2-en-1-one2×

Product 1

HCID 866001661-[2-Hydroxy-4-carboxydimethylmethyloxyphenyl]-3-[4-chlorophenyl]prop-2-en-1-one

Procedure

This compound was synthesized from 2′-hydroxy-4′-ethyloxycarbonyldimethylmethyloxyacetophenone (starting material 1) and 4-chlorobenzaldehyde according to general method 2 described earlier.

Sources & evidence

ORD record: ord-6252afdb2db04c7da7f78039c15fa27c
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08058308B2

Reaction notes

Loading…