Hydrochloric Acid → Metformin Hydrochloride

HRID 556771Notes

Reaction equation

HRID 556771 reaction equation
[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[ClH:10]>CC(C)=O>[CH3:1][N:2]([C:4]([N:6]=[C:7]([NH2:9])[NH2:8])=[NH:5])[CH3:3].[ClH:10]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178484382HCID 178484382, compound

Product 1

HCID 14219Metformin HydrochlorideYield 76.4%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

500 mg of metformin free base was dissolved in 30 Ml of acetone, and then 280 Ml of concentrated hydrochloric acid was added, and stirred for 2 hours at room temperature. The resulting crystal was filtered and washed with acetone, and then dried with heated air at 70° C. to obtain 490 mg of metformin hydrochloride (yield: 76.4%).

Workup

  1. filtrationThe resulting crystal was filtered
  2. washwashed with acetone
  3. customdried
  4. temperaturewith heated air at 70° C.

Sources & evidence

ORD record
ord-443ef9fe6acd4d6785e095ccf7bab1ab
Source dataset
uspto-grants-2011_11
Patent number
US08058312B2

Reaction notes

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