反应详情

温度

200 °C

A mixture of 4,5-dichloropyridin-2-amine (300 mg, 1.84 mmol) and morpholine (480 mg, 5.52 mmol) in DMA (3.6 mL) was heated at 200° C. for 60 minutes by microwave irradiation. The mixture was purified by ion exchange chromatography on SCX-II acidic resin (2 g) eluting with methanol, then 2M ammonia-methanol. The basic fractions were combined and solvent was evaporated. Flash chromatography on silica, eluting with ethyl acetate-hexane (1:1) gave 5-chloro-4-morpholinopyridin-2-amine as a colourless solid (347 mg, 88%).

1. customThe mixture was purified by ion exchange chromatography on SCX-II acidic resin (2 g)
2. washeluting with methanol
3. customsolvent was evaporated
4. washFlash chromatography on silica, eluting with ethyl acetate-hexane (1:1)