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To a chilled solution of 4-(4-chloro-phenyl)-4-cyano-piperidine-1-carboxylic acid tert-butyl ester (315 mg, 1 mmol) in 5 ml dichloromethane was added 1 ml trifluoroacetic acid. The reaction was stirred at 0° C. for 3 hours, then concentrated under vacuum. The resulting oil was diluted with dichloromethane and washed twice with saturated aqueous sodium bicarbonate. The aqueous washings were extracted three times with dichloromethane. The combined organic layers were dried with magnesium sulfate and concentrated under vacuum to yield the title compound (180 mg, 82%).

1. concentrationconcentrated under vacuum
2. additionThe resulting oil was diluted with dichloromethane
3. washwashed twice with saturated aqueous sodium bicarbonate
4. extractionThe aqueous washings were extracted three times with dichloromethane
5. dry with materialThe combined organic layers were dried with magnesium sulfate
6. concentrationconcentrated under vacuum