反应详情

A mixture of 4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidine (2.2 g, 10 mmol), K2CO3 (1.6 g, 11.6 mmol) and 2-toluenesulfonyl-2-phenyl-1,3-indandione (4.2 g, 10 mmol) in acetonitrile (50 ml) was heated at reflux for 3 hours. The mixture was cooled and the insolubles were filtered. The solvent was removed on a rotary evaporator. The residue was purified twice using a flash chromatography column (SiO2, 45 g and 40 g; eluted with DCM). The product thus purified was recrystallized from ethanol (30 ml) and isopropyl ether, yield: 2.8 g, m.p. 149°-150° C.

1. temperaturewas heated
2. temperatureat reflux for 3 hours
3. temperatureThe mixture was cooled
4. filtrationthe insolubles were filtered
5. customThe solvent was removed on a rotary evaporator
6. customThe residue was purified twice
7. washa flash chromatography column (SiO2, 45 g and 40 g; eluted with DCM)
8. customThe product thus purified
9. customwas recrystallized from ethanol (30 ml) and isopropyl ether, yield: 2.8 g, m.p. 149°-150° C.