3-Thiophenecarboxaldehyde → HCID 11639091, compound

HRID 557101Notes

Reaction equation

HRID 557101 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]([CH:6]=O)=[CH:2]1.C([CH2:11][S:12]([CH2:15][S:16]([CH2:19][C:20](O)=O)(=[O:18])=[O:17])(=[O:14])=[O:13])(O)=O>C(O)(=O)C>[S:1]1[CH:5]=[CH:4][C:3](/[CH:6]=[CH:11]/[S:12]([CH2:15][S:16](/[CH:19]=[CH:20]/[C:3]2[CH:4]=[CH:5][S:1][CH:2]=2)(=[O:18])=[O:17])(=[O:14])=[O:13])=[CH:2]1

Participants

4

Reactant 2

HCID 681353-ThiophenecarboxaldehydeHCID 2252641Acetic acid, 2,2'-[methylenebis(sulfonyl)]bis-

Product 1

HCID 11639091HCID 11639091, compoundYield 55%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of thiophene-3-carbaldehyde (2 mmol) and carboxymethane-sulfonylmethanesulfonyl-acetic acid (1 mmol) in acetic acid (10 mL) was subjected to General Procedure 1, to yield the title compound in 55% yield. m.p. 150-152° C.

Sources & evidence

ORD record
ord-6b151e9dedaa4212a1ed0f49055f27e6
Source dataset
uspto-grants-2011_11
Patent number
US08058313B2

Reaction notes

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